HPLC apparatus · Welcome to the Nobel Prize Laureate Collection

ID-nummer

2019.008.001

Titel

HPLC apparatus

Objektkategori

Vetenskapliga instrument, material & modeller

Publik beskrivning

This HPLC (High Performance Liquid Chromatography) apparatus was used by Robert Lefkowitz and colleagues in the early 1980s, as one of the steps to purify the beta adrenergic receptor, the first G protein coupled receptor to be purified. Drugs targeting G protein coupled receptors account for a substantial part of all drugs used in clinical medicine.
In chemistry, chromatography is an important method for separating substances. A mixture of substances dissolved in a liquid or gas is allowed to migrate through a stationary phase, for example a granular material consisting of solid particles. Because the components in the mixture interact with the grains in different ways, they will move at different speeds. In this way, the components are separated.

Robert Lefkowitz donated the HPLC apparatus to the Nobel Prize Museum in 2019.

Pristagare

Robert J. Lefkowitz